P-396 Modified Flare/GnRH antagonist protocol versus GnRH antagonist protocol in oocyte cryopreservation cycles

Abstract Study question Is there an advantage for modified flare/ GnRH antagonist protocol in comparison to oocyte cryopreservation cycles? Summary answer Modified is at least as good cycles, potentially improving maturity rate subgroup of patients. What known already Ultrashort flare agonist (GnRHa)/GnRH -antagonist offer benefits stimulatory effect repeated microdose on endogenous FSH and the advantages suppression, including option use GnRHa ovulation trigger avoid ovarian hyperstimulation syndrome. has been associated with suboptimal response that refers lesser than expected yield. Our research group previously demonstrated value follicular challenge test (FACT) prediction assessed by post LH levels a dynamic reserve (not published yet). design, size, duration A retrospective, age- matched, cohort study included all non-medical cycles from October 2020 December 2021. The 110 women received were matched protocol. Participants/materials, setting, methods Women administered (Decapeptyl 0.2 mg) day 2 menstrual cycle followed flexible They compared age In both groups final was administered. Main results role chance Among underwent fertility preservation Flare/GnRH protocol, reduced dosage gonadotropins consumed more oocytes retrieved (14.63 vs. 13.86) mature cryopreserved (11.32 10.14), but differences not significantly different. 6 flare/antagonist (14.03± 0.90 11.63± 0.71, p = 0.03) Limitations, reasons caution Limitations our are its retrospective nature lack information oocyte’s fertilization competence pregnancy outcomes. Wider implications findings Future studies will further explore this terms higher rate, intra triggering. Trial registration number applicable